How the Biofilm State Puts Bacteria to Zzzzzzz
Bacterial pathogens in the biofilm state are the etiologic agents of chronic and recurrent infections. Herein, bacteria adopt a community architecture and protect themselves against hazardous conditions (like the host immune response and antimicrobials) by creating an extracellular matrix. This matrix is made up of multiple types of biomolecules but universally contains DNA. Indeed, enzymes that degrade DNA disrupt biofilms but only early in their development; mature biofilms are completely resistant to these same enzymes. The reason for this resistance is due to a novel structure adopted by the extracellular DNA. Targeting this novel DNA structure provides a novel means to disrupt bacterial biofilms across genera and cure chronic and recurrent infections.
Open to the University public, Dental CE credit available. Light refreshments will be served.
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